Blood Vessel Formation: What Is Its Molecular Basis?
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چکیده
منابع مشابه
Blood Vessel Formation: What Is Its Molecular Basis?
but absence of information about the ligand for either of these receptors has hindered our understanding of Children's Hospital and Harvard Medical School Boston, Massachusetts 02115 their contribution to vascular development. Three papers in this issue reveal new information Medical students learning the anatomy of the human about the potential role of the TIE2 receptor and its ligand and rais...
متن کاملWhat guides early embryonic blood vessel formation?
Survival of vertebrate embryos depends on their ability to assemble a correctly patterned, integrated network of blood vessels to supply oxygen and nutrients to developing tissues. The arrangement of larger caliber intraembryonic vessels, specification of arterial-venous identity, and proper placement of major branch points and arterial-venous connections are all precisely determined. A number ...
متن کاملMolecular analysis of blood vessel formation and disease.
Blood vessels affect the quality of life in many ways. They provide an essential nutritive function during growth and repair of tissues but, on the other hand, can become affected by disorders or trauma, resulting in bleeding, thrombosis, arterial stenosis, and atherosclerosis. Three molecular systems, the vascular endothelial growth factor (VEGF) system, the plasminogen system, and the coagula...
متن کاملXRASGRP2 is essential for blood vessel formation during Xenopus development.
Ras guanyl nucleotide-releasing protein 2 (RASGRP2), one of the Ras guanine exchange factors, is implicated as a critical regulator of inside-out integrin activation in human lymphocytes, neutrophils and platelets. However, the activities of this protein in endothelial cells remain unclear. In the current study, we identify a physiological function in blood vessel formation for XRASGRP2, which ...
متن کامل[Molecular basis of bone metastasis formation and its targeted therapy].
Formation of bone metastasis is a hallmark of the progression of several solid cancers, providing example for the organ specificity of the process. Bone metastasis may result in both venous and arterial dissemination. Though the molecular basis of the lytic and plastic bone metastasis formation is different, in reality these organ metastases represent a mixture of the two processes. The basis o...
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ژورنال
عنوان ژورنال: Cell
سال: 1996
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81810-3